Hydroxypropyl-Gamma-Cyclodextrin
Hydroxypropyl γ-cyclodextrin is a modified cyclodextrin obtained by introducing hydroxypropyl groups onto the γ-cyclodextrin molecule. This modification enhances the solubility and stability of cyclodextrin, making it more suitable for use in the fields of medicine, chemistry, and biology. Hydroxypropyl γ-cyclodextrin is usually used as a carrier molecule and is employed in pharmaceutical preparations to improve the stability, solubility, and bioavailability of drugs. Its main function is to encapsulate drug molecules, thereby improving the solubility of drugs, promoting drug absorption, reducing adverse drug reactions, and enhancing drug efficacy.
Product Basic Information
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Chinese Name |
Hydroxypropyl Gamma Cyclodextrin |
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Alternative Names |
Hydroxypropyl-γ-Cyclodextrin; Hydroxypropyl-GAMMA-Cyclodextrin |
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English Name |
Hydroxypropyl-Gamma-Cyclodextrin; Hydroxypropyl-γ-Cyclodextrin |
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Abbreviation |
HP-γ-CD |
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CAS No. |
128446-34-4 |
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Molecular formula |
C48H80-nO40(C3H7O)n, where n represents the degree of substitution. |
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Molecular weight |
1297.2 + 58n, where n represents the degree of substitution. |
Quality standard
| Hydroxypropyl-Gamma-Cyclodextrin | |||
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Inspection Standard |
ChP2020 |
USP-NF2024 |
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Test items |
Enterprise Standards |
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Properties |
This product is a white or off-white amorphous or crystalline powder, odorless, slightly sweet, and highly hygroscopic. It is highly soluble in water, easily soluble in ethanol, and almost insoluble in acetone. |
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pH |
5.0～8.5 |
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Solution clarity and color |
Should be clear and colorless |
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Impurity absorbance |
The absorbance within the wavelength range of 220-350nm shall not exceed 0.5 The absorbance within the wavelength range of 350-750nm shall not exceed 0.5 |
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Conductivity |
≤200µs/cm |
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Chloride |
≤0.05% |
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Hydroxypropoxy content |
17.5%～29.1% |
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Water content |
≤6.0％ |
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Related Substances |
Gamma cyclodextrin |
≤1.5% |
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1,2-propylene glycol |
≤0.5％ |
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Other single impurities (except gamma cyclodextrin and 1,2-propylene glycol) |
≤0.1% |
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Total of other impurities (except gamma cyclodextrin and 1,2-propylene glycol) |
≤1.0% |
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Residue on ignition |
≤0.2％ |
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Heavy metals |
≤10ppm |
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Propylene oxide |
≤1ppm |
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Microbial Limits |
Total aerobic bacteria |
≤1000cfu/g |
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Total mold and yeast count |
≤100cfu/g |
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Escherichia coli |
Not detectable |
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Salmonella |
Not detectable |
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Bacterial endotoxins |
According to the preparation requirements |
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Product Features
Hydroxypropyl γ-cyclodextrin can dissolve macromolecules such as cholesterol and is used for cell culture. This product is white amorphous or ultrafine granules; it has no odor and a slightly sweet taste; it is highly hygroscopic. It is highly soluble in water and easily soluble in ethanol, but almost insoluble in acetone. Hydroxypropyl γ-cyclodextrin is similar to β-cyclodextrin, but it can dissolve larger molecules.
Product Usage
Hydroxypropyl γ-cyclodextrin has high water solubility and stronger anti-crystallization ability. After hydroxypropylation, γ-cyclodextrin is no longer a single pure substance but a mixture of various substituents. When complexed with guest molecules, it is less likely to form crystalline precipitates of inclusion complexes. Meanwhile, the water solubility of hydroxypropyl γ-cyclodextrin is further enhanced to 80g/100ml (25°C). This product is recommended for high value-added products, such as medicines, health supplements, cosmetics and other special materials, or for treating larger molecules that cannot be complexed with hydroxypropyl-β-cyclodextrin. It is suggested to be used in higher value-added products, such as medicines, health supplements, cosmetics and other special materials or for treating larger molecules that cannot be complexed with hydroxypropyl-β-cyclodextrin.
Packaging and Storage
- Packaging Specifications: 100g/500g/1kg/2kg/10kg
- Packaging Form: Medical low-density polyethylene bag + full paper barrel or cardboard barrel
- Storage Method: Store in a dark place and sealed
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