Methyl-Beta-Cyclodextrin

Methyl-Beta-Cyclodextrin is a white powder; odorless, with a slightly sweet taste. Methyl-Beta-Cyclodextrin is a methylated derivative of Beta-Cyclodextrin. In its molecular structure, the hydroxyl groups of Beta-Cyclodextrin are replaced by methyl groups. It has good solubility in water, and its solubility increases with the increase of substitution degree. However, when the substitution degree reaches 13-14, its solubility begins to decrease. It is relatively stable under neutral or weakly acidic conditions. Methylated cyclodextrins have a large surface tension, and are particularly effective in increasing water solubility for oil-soluble molecules.

Basic Information Introduction

Chinese Name	Methyl Beta-Cyclodextrin
Alternative Names	Methyl-β-Cyclodextrin, Methyl-beta-Cyclodextrin
English Name	Methyl-Beta-Cyclodextrin; Methyl-β-Cyclodextrin
Abbreviation	MEBCD
CAS Number	128446-36-6
Molecular Formula	C₄₂H₇₀-nO₃₅ · (CH₃)n
Molecular Weight	1135 + n•(14.0)

Testing Standards

Test items	Enterprise standard
Properties	This product is white powder; odorless, slightly sweet; easily soluble in water and methanol, easily soluble in ethanol and ethylene glycol, almost insoluble in cyclohexane and ethyl acetate
Content	≥98%
Specific rotation	+154°～+165°
pH	pH5.0～7.5
Clarity of solution	2.5g/25ml aqueous solution is clear
Absorbance of impurities	The absorbance within the wavelength range of 220～350nm shall not exceed 1.0 The absorbance within the wavelength range of 350～750nm shall not exceed 0.1
Average degree of substitution	7.0~13.3
Loss on drying	≤7.0％
Beta-cyclodextrin	≤0.2%
Ignition residue	≤0.5%
Heavy metals	≤10ppm
Chloride	≤0.2%
Total number of aerobic bacteria	≤1000cfu/g
Total number of molds and yeasts	≤100cfu/g
Escherichia coli	Not to be detected

Product Performance

Due to the excellent solubilizing and encapsulating effects of M-β-CD, and because it is soluble in both water and organic solvents, it is widely applied in medicine, food, pesticides, cosmetics, daily chemicals, chemical industry, textile dyeing and finishing, chromatographic analysis, and functional materials. Specifically, it can:

1. Increase solubility and utilization rate, enhancing the effect or reducing the dosage;

2. Adjust or control the release rate of the encapsulated substances;

3. Enhance the stability of the encapsulated substances, especially being more effective in increasing water solubility for oil-soluble molecules.

Common Application Fields And Uses

Medicine Field

Methyl beta-cyclodextrin can be used as a pharmaceutical excipient to enhance the solubility and stability of drugs, and increase the bioavailability of drugs. For example, it can form inclusion complexes with some poorly soluble drugs, thereby improving the water solubility of the drugs.

Food Field

It can be used as a food additive to improve the taste and stability of food.

Cosmetics Field

In cosmetics, methyl beta-cyclodextrin can be used to improve the stability and solubility of active ingredients.

Chemical Analysis

It can be used for the separation and purification of target compounds.

Wastewater Treatment

The cavity structure of methyl beta-cyclodextrin can remove pollutants through host-guest inclusion complexation, such as heavy metals and dyes.

Safety Information

Avoid direct contact with skin and eyes. In case of contact, rinse immediately with clean water. Store in a dry and ventilated place, away from fire sources and oxidants. When exposed to high temperature or fire sources, it may decompose and generate harmful gases. Such situations should be avoided. Methyl beta-cyclodextrin has attracted attention and applications in multiple industries due to its unique properties and broad application prospects.